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LOS ANGELES — Christina Applegate has kept her fans in the loop regarding her battle with multiple sclerosis since she was diagnosed three years ago. Her latest update? “I don’t enjoy living. I don’t enjoy it.

I don’t enjoy things anymore.” The “Dead to Me” and “Married..



. With Children” TV star, 52, said her depression recently returned after more than 20 years as she got brutally honest about the mental toll of her battle with MS. “I give up so easily,” she told her “MeSsy” podcast co-host, “Sopranos” actor Jamie-Lynn Sigler, in an episode published Tuesday.

Applegate announced in 2021 she had been diagnosed with MS, an autoimmune disease that affects the central nervous system and can result in progressive physical and cognitive decline. Since unveiling her diagnosis, the Emmy winning actor has been open about her condition — from the 30 lesions on her brain to the difficulty and discomfort of attending all-day Hollywood events like the 2023 Emmy Awards, where her colleagues celebrated her with a standing ovation. Applegate said on the podcast that she becomes discouraged and hopeless easily and that caring for her teenage daughter is one of the few things motivating her amid her illness.

“I’m in a depression right now which I don’t think I’ve felt that for years, like a real, f—-it-all depression,” Applegate said. “Like real depression, where it’s kind of scaring me too a little bit because it feels really fatalistic, it f.

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