DNA fragmentation refers to the presence of fragmented DNA within sperm cells where high levels of fragmented DNA can hinder the ability of sperm to fertilise eggs effectively, leading to infertility , the creation of poor-quality embryos and an increased risk of miscarriage . The DNA Fragmentation Index (DFI) is a specialised test that measures the extent of DNA fragmentation in sperm. Male infertility: Strategies to manage high DNA fragmentation in sperm for improved fertility in men (Image by Freepik) In an interview with HT Lifestyle, Dr Sneha Sathe, Fertility Consultant at Nova IVF Fertility in Chembur, shared, “Although not routinely recommended for all couples experiencing fertility issues, the DFI test is advised in certain situations.
These include long-standing infertility, multiple failed intrauterine insemination (IUI) cycles, previous IVF cycles with poor embryo quality, or low blastulation rates (The percentage of embryos that reach the blastocyst stage and are ready to go for transfer or freezing).” Unlock exclusive access to the latest news on India's general elections, only on the HT App. Download Now! Download Now! Causes of High DFI According to Dr Sneha Sathe, several factors can contribute to high DFI, including: • Infections • Environmental pollution • Lifestyle choices such as smoking, alcohol, and drug use • Medical conditions like diabetes, obesity Impact of High DFI on IVF/ICSI Cycles Dr Sneha Sathe revealed, “High DFI can negatively af.
