In a recent review published in the journal Signal Transduction and Targeted Therapy , researchers examined the in vivo evidence on signal transduction across various tissues induced by “exerkines,” a group of molecules released during exercise. They highlighted the preventive and therapeutic potential of exerkine signaling. They explored the molecular mechanisms of exerkine secretion, signaling pathways, and their implications in disease prevention and treatment.
Review: Molecular insights of exercise therapy in disease prevention and treatment . Image Credit: BGStock72 / Shutterstock Physical inactivity is linked to various chronic diseases, while physical activity is known to help prevent them. Exercise training, involving structured, repeated bouts of activity, serves as a cost-effective intervention to improve health and prevent conditions like cancer, cardiovascular, metabolic, and neurodegenerative diseases.
Acute exercise regulates physiological parameters to meet the demands of active tissues, leading to long-term tissue adaptations that enhance and protect overall health. Despite known benefits, the molecular mechanisms of these adaptations are not fully understood. Researchers have identified exerkines, exercise-induced molecules that mediate tissue communication and drive adaptations.
Understanding exerkine kinetics and dynamics is crucial for optimizing exercise prescription for disease prevention and treatment and developing exercise-mi.
