University of Queensland researchers have unlocked crucial molecular secrets of aging in cells, potentially paving the way to improve quality of life as people age. The study decoded the process by which genes regulate how people mature as they grow and age, and was led by Dr. Christian Nefzger from UQ's Institute for Molecular Bioscience with key contributions from Dr.
Ralph Patrick and Dr. Marina Naval-Sanchez. Dr Nefzger said that until now the process of how genes change activity from birth to adulthood and into old age was largely unknown.
By analyzing molecular datasets from both people and mice and then comparing different age groups over time, we investigated the activity of genes involved in both developmental and ageing processes. Master controller genes regulate which genes are turned on or off in each of our cells, making sure that each cell does its specific job, just as a conductor directs musicians to produce different sounds. We followed the activity of the master regulator Activator Protein 1 or AP-1 and found that it progressively activated adult genes, whilst the activity of 'early-life' genes involved in development were dialled down, and this process was shared across cell types.
" Dr. Christian Nefzger from UQ's Institute for Molecular Bioscience Dr Naval-Sanchez said the study found this process in our cells was predictable across the different life stages, as people mature. "It was ongoing in adulthood, likely because AP-1 is also activated by a number.