Most patients with thyroid eye disease treated with teprotumumab didn't require additional treatments nearly 2 years later, according to industry-supported research being presented Sunday at ENDO 2024, the Endocrine Society's annual meeting in Boston, Mass., and published in the journal Thyroid. Thyroid eye disease is a lifelong autoimmune disease that can worsen or flare, regardless of how it has been treated.
This is the case for many autoimmune diseases. Given the enduring nature of thyroid eye disease, it is important to understand whether patients who are treated with a full course of teprotumumab (eight infusions) can expect to experience lasting improvements in signs and symptoms, like eye bulging and double vision." George Kahaly, M.
D., Ph.D.
, professor of medicine and endocrinology at Johannes Gutenberg University Medical Center in Mainz, Germany Due to the longevity of thyroid eye disease, Kahaly added, it was important to look at longer-term results after treating patients with teprotumumab. Kahaly and colleagues sought to answer whether or not patients with thyroid eye disease would see sustained improvements in eye bulging (proptosis) and double vision (diplopia). The study was sponsored by Amgen, which manufactures teprotumumab.
The researchers analyzed pooled clinical trial data beyond the 24-week treatment period for patients in phase 2, OPTIC, and OPTIC-X studies who received a full course of teprotumumab, up to week 72 (51 weeks post-final teprotumumab infus.