In a recent study published in the journal Science Advances , researchers estimated the maximal longevity, gestation period, and sexual maturity age using deoxyribonucleic methylation (DNAm) by examining 15,000 samples from 348 mammalian species. The Mammalian Methylation Consortium has collected DNA methylation data from 348 animals to examine mammalian species' maximal longevity. An improved understanding of the molecular pathways that determine this life span is required, which is currently poorly known due to limited sample sizes and data-gathering methods.
The collection covers research on mammalian age-associated methylation alterations, epigenetic aging, machine-learning techniques, and phylo-epigenetic modeling trees. Study: Epigenetic predictors of species maximum life span and other life-history traits in mammals . Image Credit: Craig Lambert Photography / Shutterstock In the present study, researchers created multivariate regressions to estimate maximal longevity and related species-specific features.
The researchers developed regression models using the Mammalian Methylation Consortium data, emphasizing highly conserved patterns of cytosine methylation from 15,000 deoxyribonucleic acid samples from 59 types of tissues and 348 mammalian species from 25 taxonomic groups. The researchers produced universal sex predictions based on CpG methylation levels that apply to all mammalian species except marmosets. The researchers utilized three penalized regression models to.