In a recent study published in Nature Medicine , a group of researchers used lipidomics data to develop a multilipid score (MLS). It reduced MLS (rMLS) to assess the impact of dietary fat quality on lipid metabolites and its association with reduced cardiometabolic disease risk. Study: Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition .
Image Credit: puhhha/Shutterstock.com Cardiovascular diseases (CVDs) (Disorders of the heart and blood vessels, like heart attack and stroke) cause 20 million global deaths annually, and type 2 diabetes (T2D) (A chronic condition with high blood sugar due to insulin issues) contributes significantly to the noncommunicable disease burden. Reducing CVD and T2D incidence offers substantial societal benefits.
World Health Organization (WHO) and national guidelines recommend reducing saturated fats and increasing unsaturated fats to prevent cardiometabolic diseases. However, the role of dietary fat in cardiometabolic health remains debated, especially regarding high-fat, low-carbohydrate diets (LCDs) versus reducing saturated fats. The impact of replacing animal-based saturated fats with plant-based unsaturated fats on cardiometabolic risk is unclear.
Further research is needed to clarify these effects and understand the genetics, physiology, and diet interplay in lipid metabolism. Lipidomics analysis was performed on 113 participants from the 16-week Dietary Intervention and VAScular.