Newswise — In recent years, messenger RNA (mRNA) has emerged as a promising avenue for accurate and potent therapeutic interventions. Unlike DNA drugs, mRNA can express genetic information without the risk of integrating into the host genome. However, challenges in delivery efficiency have spurred the development of advanced technologies such as lipid and polymeric nanoparticles, as well as biomimetic carriers inspired by viral mechanisms.
These innovations aim to boost mRNA stability, enhance cellular uptake, and pave the way for safer and more effective therapies. In a recent review article published on May 7, 2024 in Volume 6 of BioDesign Research , a team of scientists led by Professor Feng Li and Professor Xinying Wang from the University of Chinese Academy of Sciences explored the promising frontier of mRNA therapeutics using protein nanocages (PNCs). Explaining the motivation behind their study, Prof.
Li elucidates “Within this landscape of advancing mRNA delivery techniques, PNCs have emerged as pivotal tools. These nanostructures offer several advantages crucial for effective drug delivery. Their customizable surface area and volume enable specific targeting, high cargo capacity, and efficient uptake by cells, addressing key challenges in mRNA therapy .
” Moreover, PNCs protect payloads (drugs they carry) from premature degradation and biological interactions, enhancing their potential for tissue-specific delivery. They are biodegradable in vivo (inside living s.