In a recent study published in the journal Nature Medicine , a team of researchers in China conducted a prospective analysis of metabolic multimorbidity clusters based on 21 metabolic parameters to investigate gut microbiome signatures associated with metabolism and age to better understand the relationship between metabolism, age, and the long term risk of cardiovascular disease. Study: Divergent age-associated and metabolism-associated gut microbiome signatures modulate cardiovascular disease risk . Image Credit: Kateryna Kon / Shutterstock Cardiovascular disease is the major cause of global mortality, and metabolic perturbations and age, which are also intricately connected, are believed to contribute significantly to the risk of cardiovascular disease.
Metabolic disturbances increase in complexity and prevalence with age, and older adults typically develop cardiovascular disease in a multimorbidity context. Growing evidence on aging patterns associated with gut microbiome diversity across populations suggests that the gut microbiome interconnects immunity and metabolism, undergoes age-related changes, and could be the basis of healthy aging. Studies have found that lower diversity of Bacteroides and increased diversity of unique taxa in the gut microbiome were linked to healthy aging.
However, the interaction patterns between the gut microbiome, metabolism, and age and the extent to which these interactions influence cardiovascular health remain unclear. In the present st.