A recent study published in eBioMedicine performed a multi-omics analysis of host-microbe interactions in psoriasis. Psoriasis is a common systemic inflammatory disease that affects up to 3% of the global population. It can cause comorbidities such as diabetes, psoriatic arthritis, and cardiovascular disease.
Based on disease characteristics, there are several clinical subtypes of psoriasis. Various factors, such as the epidermal barrier, environmental factors, and the immune system, have been implicated in the development and progression of psoriasis. Psoriasis lacks a definitive cure and remains a significant psychological and economic burden.
Psoriatic skin microbiome varies in composition and diversity compared to healthy skin. Host-microbe interactions have been suggested to be involved in psoriasis development. Further, skin microbiome dysbiosis has been reported in psoriasis; however, research on interactions between the microbiota and host using multilayer omics data is lacking.
In the present study, researchers conducted a multi-omics analysis of host-microbe interactions in psoriasis. They used data from the microbes in allergy and autoimmunity related to the skin (MAARS) cohort. Individuals with plaque-type psoriasis and healthy volunteers were recruited.
People with autoimmune diseases, recent antibiotic use, phototherapy, biologics use, or immunosuppressive therapy were excluded. Skin biopsies and microbiome samples were obtained from active disease sites and adj.