Mirna Chehade, MD, MPH Credit: Mount Sinai Treatment with weight-tiered higher dose dupilumab led to significant and sustained improvements in key histologic, endoscopic, and cellular measures of eosinophilic esophagitis (EoE) in children 1-11 years of age, according to phase 3 data from the EoE KIDS trial. 1 Results were published in New England Journal of Medicine and suggest dupilumab’s potential to change the standard of care for young children with EoE, a population for whom there were no US Food and Drug Administration-approved medications prior to dupilumab’s expanded approval for children 1-11 years of age with EoE on January 25, 2024. 1,2 A randomized, double-blind, placebo-controlled phase 3 trial, EoE KIDS assessed the efficacy and safety of dupilumab in children aged 1-11 years with EoE.
Part A enrolled 102 patients and evaluated dupilumab at a weight-tiered higher dose or lower dose regimen for 16 weeks, while Part B was a 36-week extended active treatment period in which eligible children in the dupilumab group from Part A maintained their higher or lower dose level, while those in the placebo group switched to higher or lower dose dupilumab. Of note, the trial is ongoing with a 108-week open-label extension period (Part C) to evaluate longer-term outcomes. 3 In Part A, histologic remission was observed among 68% of participants in the higher-exposure arm, 58% of subjects in the lower-exposure arm, and 3% of those in the placebo arm, with a 65 percentage poi.