Researchers have linked a genetic variant that deactivates the SMIM1 gene to increased obesity risk. The findings could lead to new obesity treatments and help reduce related stigma. Researchers have discovered a new cause of why people who lack a specific blood group are genetically predisposed to be overweight or obese.
A genetic study led by the University of Exeter identified a link between the SMIM1 gene variant and obesity. This variant, found in individuals without the Vel blood group, causes decreased resting energy expenditure and could impact around 300,000 people globally. Genetic Link to Obesity Found in Blood Group Research A team of international scientists, led by the University of Exeter, discovered that people with a genetic variant that disables the SMIM1 gene have higher body weight because they expend less energy when at rest.
SMIM1 was only identified 10 years ago, while searching for the gene encoding a specific blood group, known as Vel. One in 5,000 people lack both copies of the gene, making them Vel-negative. The findings from the new research suggest that this group is also more likely to be overweight, a conclusion that could one day lead to new treatments.
The study found that people without both copies of the gene have other measures linked to obesity including high levels of fat in the blood, signs of fat tissue dysfunction, increased liver enzymes as well as lower levels of thyroid hormones. Implications for Healthcare and Treatment The study w.