SAN FRANCISCO and SUZHOU, China , June 25, 2024 /PRNewswire/ -- Innovent Biologics, Inc. (Innovent) (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high-quality medicines for the treatment of oncology, autoimmune, cardiovascular and metabolic, ophthalmology and other major diseases, reports the results of liver fat content from the Phase 3 study of mazdutide in Chinese adults with overweight or obesity (GLORY-1) at the ADA scientific sessions 2024. Mazdutide (Innovent R&D code: IBI362) is a glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) dual agonist.
By activating GLP-1R, it reduces appetite and delays gastric emptying, thereby achieving weight loss. At the same time, through activation of GCGR, it increases energy expenditure, enhances fatty acid oxidation and lipolysis, and reduces liver fat. Professor Linong Ji , the leading principal investigator of the study, Peking University People's Hospital, stated, "Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most common chronic liver diseases in the world and the most common comorbidity in overweight and obese people in China .
Metabolic dysfunction-associated fatty liver disease (MASH) and MAFLD are significant unmet clinical needs, making them hot spots for innovative drug development in the field of metabolism. In recent years, the potential of GLP-1 drugs in improving MAFLD and MASH has begun to be realized. Yet, due to .