( MENAFN - PR Newswire) SOUTH SAN FRANCISCO, Calif., May 23, 2024 /PRNewswire/ -- IDEAYA Biosciences, Inc. (Nasdaq: IDYA ), a precision medicine oncology company committed to the discovery and development of targeted therapeutics, today announced the publication of the abstract for an oral presentation of preliminary clinical results from its investigator-sponsored Phase 2 trial of darovasertib, a first-in-class oral, small molecular inhibitor of protein kinase C (PKC), as neoadjuvant/adjuvant treatment in uveal melanoma (UM) at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting.
Anthony Joshua, MBBS, PhD, FRACP, Head Department of Medical Oncology, Kinghorn Cancer Centre, St. Vincent's Hospital in Sydney, who is the leading principal investigator of the Phase 2 study, will present the clinical data from the Phase 2 Neoadjuvant / Adjuvant trial of Darovasertib in Ocular Melanoma" (NADOM) study. Details of the presentation are as follows: In summary, 15 patients planned for enucleation with localized UM were treated with darovasertib 300mg twice daily.
An initial safety cohort of 3 patients were treated for one month, and the remaining 12 patients were treated in an expansion cohort for up to six months as neoadjuvant treatment prior to their primary intervention (enucleation, plaque brachytherapy or external beam radiotherapy (EBRT)) across three Australian centers. As of the database lock, 11 patients had completed primary treatment , four remained on neoad.