( MENAFN - PR Newswire) -Patented methods relate to multiple allogeneic CAR T-cell therapies under clinical development for the treatment of B-cell lymphoma, chronic lymphocytic leukemia, multiple myeloma, and renal cell carcinoma -Patented methods also relate to engineered tumor-infiltrating lymphocyte ("TIL") therapies under clinical development for the treatment of melanoma and non-small cell lung cancer CAMBRIDGE, Mass., May 28, 2024 /PRNewswire/ -- Factor Bioscience Inc., a Cambridge, Massachusetts-based biotechnology company pioneering mRNA-based cell engineering, today announced that the United States Patent and Trademark Office (USPTO) has terminated three separate ex parte reexaminations of three U.
S. patents owned by Factor. These three patents, which, as a result of this action, remain in effect, relate to methods for producing gene-edited cells using mRNA encoding transcription activator-like effector nucleases (TALENs), a type of gene-editing protein.
The methods covered by these patents have wide-ranging applications in therapeutic gene editing, including allogeneic CAR T-cell therapies under clinical development for a range of hematologic malignancies and solid tumors including large B-cell lymphoma (LBCL), chronic lymphocytic leukemia (CLL), multiple myeloma (MM), and renal cell carcinoma (RCC). In these therapies, mRNA encoding TALENs is used to inactivate the endogenous T-cell receptor to prevent therapeutic T cells from causing graft-versus-host-disease (Gv.