In a recent review published in Alzheimer's & Dementia , researchers investigated sex-related and gender-specific resistance and resilience factors in Alzheimer's disease (AD). Sex and gender have a crucial role in determining protective and risk factors for AD. Understanding these characteristics is critical to improving our understanding of the resilience and resistance mechanisms that sustain cognitive function while reducing pathology buildup in aging and AD.
Inter-individual diversity exists in the response to AD pathology, with a few older individuals staying cognitively intact. A sex- and gender-aware resilience paradigm in AD should go beyond defining differences to gain full knowledge of cognitive decline and dementia prevention. In the present review, researchers discussed sex- and gender-specific determinants of resistance and resilience in AD.
AD researchers are reaching an agreement on the difference between managing and preventing AD diseases. Researchers use the words resistance (avoiding) and resilience (coping) to distinguish between characteristics that might help prevent AD development from neurodegeneration and clinical manifestations of the illness. In AD, the term resilience indicates the capability of mitigating the negative impact of risk and pathology on cognitive function.
Resistance against pathologies in AD indicates the premise that particular individuals may exhibit a low to negligible pathological load despite increased risk. This hypothesis ass.