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Thursday, Merus N.V. MRUS announced the publication of an abstract regarding petosemtamab in combination with pembrolizumab on the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting website .
Keytruda (pembrolizumab) is Merck & Co Inc’s MRK top selling cancer drug. The abstract presents interim clinical data from a cohort of 26 patients enrolled as of the abstract cutoff date, evaluating the combination in first-line (1L) recurrent/metastatic (r/m) head and neck squamous cell carcinoma (HNSCC). As of a November 6, 2023, data cutoff date: Ten patients were evaluable for response, and six responses were observed.
This included 1 confirmed complete response, 2 confirmed partial responses, and three unconfirmed partial responses (2 confirmed as of the abstract submission and the 3rd also subsequently confirmed). The combination was well tolerated, and no significant overlapping toxicities were observed. Treatment-emergent adverse events were reported in all patients; most were Grade 1 or 2 in severity.
Infusion-related reactions (composite term) were reported in 26.9% (all Grades), of which 3.8% were Grade 3.
All occurred during the first infusion and were resolved. The poster concluded that petosemtamab, in combination with pembrolizumab, demonstrates a well-tolerated safety profile and promising preliminary clinical efficacy. William Blair writes that overall, the abstract disclosed a response rate of 60% in 10 patients.
While this is clear.
