In a recent study published in the journal Nutrients , researchers examined the dynamics of fasting-induced ketosis. Long-term fasting is a potent non-pharmacologic intervention for chronic disease prevention and management. It normalizes glucose and lipid metabolism, reduces oxidative stress, restores gut microbiota balance, and has anti-inflammatory effects.
Nevertheless, fasting-induced ketosis is often compared to diabetic ketoacidosis. The metabolic switch to endogenous energy sources is a hallmark of fasting. Glucose and insulin levels drop when food intake is interrupted, leading to glucagon secretion and glycogen breakdown into glucose.
Lipolysis occurs when glycogen reserves are exhausted, releasing fatty acids into the bloodstream as the energy source. In the liver, fatty acids are converted into ketone bodies. Ketone bodies are energy-rich and water-soluble and can be transported to peripheral tissues for oxidation, allowing for ATP synthesis.
Study: Long-Term Fasting-Induced Ketosis in 1610 Subjects: Metabolic Regulation and Safety . Image Credit: RHJPhtotos / Shutterstock In the present study, researchers examined the interindividual differences in the dynamics of fasting-induced ketosis. People aged 18–91 who participated in a fasting program at a clinic were included.
Individuals with type 1 diabetes, cachexia, dementia, anorexia nervosa, cerebrovascular insufficiency, or cognitive diseases were excluded. Graphical Abstract Participants underwent a medical ex.
