In a recent study published in the JAMA Network Open , a group of researchers evaluated the impact of exercise, glucagon-like peptide-1 receptor agonist (GLP-1 RA) liraglutide, and their combination on bone health at the hip, spine, and forearm following diet-induced weight loss in adults with obesity. Study: Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment . Image Credit: siamionau pavel / Shutterstock Weight loss reduces obesity-related comorbidities but often leads to decreased bone mineral density (BMD) and increased bone turnover, raising fracture risk and mortality.
This bone loss is a concern across the lifespan, particularly in older adults, and is observed after gastric bypass and calorie restriction. Identifying treatments that induce weight loss while minimizing bone loss is crucial. GLP-1RAs promote weight loss by suppressing appetite.
Exercise is recommended for healthy weight loss as it preserves lean mass. Further research is needed to establish the long-term effects of GLP-1 RAs and exercise on bone health following significant weight loss, as current evidence is limited and inconsistent. The present study was conducted from August 2016 to November 2019 at Hvidovre Hospital and the University of Copenhagen.
It was approved by the Regional Ethics Committee in Denmark and the Danish Medicines Agency, following Consolidated Standards of Reporting Trials (CONSORT) guidelines. Pa.
