In a recent systematic review published in Current Issues in Molecular Biology , researchers from Portugal examined and discussed the role of oxytocin (OT) in polycystic ovary syndrome (PCOS), its association with PCOS symptoms, and the effect of OT administration. They found that PCOS is associated with reduced serum OT levels, and alterations in OT levels are linked to fertility issues and body weight, suggesting a potential role of OT dysfunction in the development of PCOS. Study: The Role of Oxytocin in Polycystic Ovary Syndrome: A Systematic Review .
Image Credit: MMD Creative/Shutterstock.com PCOS is a complex and prevalent endocrine disorder in women of reproductive age that affects their quality of life. It is characterized by polycystic ovaries, androgen excess, and ovulatory dysfunction, often leading to infertility and various metabolic, reproductive, and psychological issues.
PCOS is linked to high levels of androgen and abnormal LH/FSH (luteinizing hormone/ follicle-stimulating hormone) ratios, contributing to anovulatory infertility and increased risks during pregnancy. Biochemically, OT is a nine-amino acid-long peptide involved in cognitive, emotional, and reproductive functions. While it is generated in the hypothalamus and secreted by the posterior pituitary gland, OT receptors (OXTR) are found in various body parts, including the ovaries and prostate gland.
OT is vital for various reproductive and behavioral functions in humans, including pregnancy, parturi.
