In a recent study published in the journal Annals of Internal Medicine , researchers investigated whether short-term adverse effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger ribonucleic acid (mRNA) vaccinations are related to neutralizing antibody (nAB) responses. COVID-19 Vaccine Side Effects and Long-Term Neutralizing Antibody Response: A Prospective Cohort Study . Image Credit: peterschreiber.
media / Shutterstock SARS-CoV-2 vaccinations lower related infections, hospital admissions, and deaths; however, protection wanes with time despite booster doses. Booster vaccine uptake has been poor, with typical reasons including a perceived lack of additional benefit, a prior history of SARS-CoV-2 infections or vaccinations, and concerns regarding adverse effects. Recent data shows that more systemic symptoms post-vaccination may indicate a robust immune response.
Population health messaging may aid adoption by portraying transient vaccination-related symptomatology as positive vaccine efficacy indicators. Quantifying nAB activity is crucial since SARS-CoV-2 vaccinations have distinct effects on neutralizing antibodies , and anti-SARS-CoV-2 spike protein immunoglobulin G (anti-S IgG) and nABs are essential for protection against coronavirus disease 2019 (COVID-19). Providing nABs to animals has protected them against infection despite SARS-CoV-2 exposure in high doses.
In a human trial, nAB titers mediated above two-thirds of vaccination effecti.
