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, /PRNewswire/ -- Surgical teams at NYU Langone Health performed the into a human body in September and , and then transplanted in the summer of 2022. These procedures were done in patients declared dead based on neurologic criteria (decedents) and maintained on ventilators with the consent of their families. Demonstrating the field's progress, NYU Langone in transplanted a into a living patient.

Now two new analyses, one published online on in and the other in , reveal changes at the single-cell level in the organs and recipient's bodies before, during, and just after the xenotransplantation surgeries in the decedents. Teams of scientists had worked alongside the surgeons, taking blood and tissue samples to analyze changes in tens of thousands of collected cells. Led by researchers at NYU Grossman School of Medicine and the Broad Institute of and , the paper tracked the genetic and cellular activity in the two pig kidneys transplanted into humans, and compared them against pig kidney samples that had not been translated.



To do so, the research team used several techniques, including single-cell RNA sequencing, which determined the order (sequence) of the molecular letters making up the pig and human genes active in various cell types during the procedures. The study showed that the transplanted pig kidneys, while not rejected outright by the recipients' bodies (no immediate kidney failure), caused a strong reaction in human peripheral blood mononuclear cells (PBMCs). This se.

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