A rare gene mutation could hold the key to slowing down or even preventing early-onset Alzheimer’s. Scientists claimed the variant had a “protective” effect on people destined to develop the disease . Researchers discovered that having one copy of the “Christchurch” gene meant these high-risk people showed signs of dementia four years later than those who did not carry the variant.
The team said the findings, published in the New England Journal Of Medicine, could pave the way for innovative treatments and targeted therapies for a disease that affects 982,000 people in the UK. Dr Joseph F Arboleda-Velasquez, an associate scientist at Mass Eye and Ear teaching hospital in the US, said: “Our new study is significant because it increases our confidence that this target is not only protective, but druggable. “We think that therapeutics inspired by protected humans are much more likely to work and to be safer.
” The protective effect of the Christchurch gene was first reported in 2019 when scientists found a Colombian woman was able to stave off Alzheimer’s until her late 70s despite the disease running in her family. Aliria Rosa Piedrahita de Villegas and many of her family members carry the “Paisa” gene mutation, which causes Alzheimer’s – with memory and thinking problems developing around the mid-40s. But she was also found to carry two copies of the Christchurch gene, which meant the disease did not progress until she was well into her 70s.
Now resear.
