EMBARGOED UNTIL JULY 8, 2024, 5:00AM EST Contact: Ilana Nikravesh Mount Sinai Press Office 212-241-9200 [email protected] Pulsed Field Ablation Procedures Found Safe and Effective for Atrial Fibrillation Patients Mount Sinai-led study demonstrates significant safety outcomes and could lead to more frequent use of this new technology Newswise — (New York, NY – July 8, 2024) – Pulsed field ablation (PFA) is safe for treating patients with common types of atrial fibrillation (AF), according to the largest study of its kind on this new technology, led by the Icahn School of Medicine at Mount Sinai. The “MANIFEST-17K” international study is the first to show important safety outcomes in a large patient population, including no significant risk of esophageal damage, with PFA. PFA is the latest ablation modality approved by the Food and Drug Administration that can be used to restore a regular heartbeat.
The findings, published July 8 in Nature Medicine, could lead to more frequent use of PFA instead of conventional therapies to manage AF patients. “MANIFEST-17K provides confidence that, unlike conventional thermal ablation, PFA with the pentaspline catheter does not cause the most feared complication of AF ablation—esophageal damage—nor does it cause pulmonary vein stenosis or persistent injury to the diaphragm,” says senior author Vivek Reddy, MD, The Leona M. and Harry B.
Helmsley Charitable Trust Professor of Medicine in Cardiac Electrophysiology at Icahn Mount.
