In today’s fast-paced world, stress often leads to inadequate sleep, causing short sleep durations or insomnia. This can induce inflammation, increasing the risk of chronic diseases. Participants took 81 milligrams of aspirin daily.
Under sleep restriction, they slept four hours each for five nights, followed by three nights of recovery sleep at eight hours per night. The control group maintained eight hours of sleep throughout. Additionally, sleep deprivation disrupts the normal function of the brain’s internal cleaning system, known as the glymphatic system.
During deep sleep, cerebrospinal fluid washes through the brain, clearing out beta-amyloid proteins associated with brain cell damage. Without adequate sleep, this cleaning process is incomplete, leading to a buildup of the protein and subsequent inflammation. This creates a vicious cycle where beta-amyloid accumulation in the frontal lobe further impairs deep sleep, making it increasingly difficult to retain and consolidate memories.
Notably, cumulative sleep loss can decrease the structural integrity, size, and function of brain regions such as the hippocampus and thalamus. These regions are particularly vulnerable to damage in the early stages of Alzheimer’s disease. Dr.
Schuyler Jones, the study’s lead author and assistant professor of medicine at the Duke Clinical Research Institute at Duke University School of Medicine, stated in a press release that the 81-milligram dose had better long-term adherence, so.
