A genetic glitch is a contributor to two worldwide health problems -- obesity and postpartum depression Researchers who discovered the gene flaw found a potential solution in mice The study began in two boys with severe obesity, anxiety and behavior problems MONDAY, July 8, 2024 (HealthDay News) — Researchers have identified a gene that can trigger obesity, behavior problems and when missing or damaged. The finding could lead to new treatments for postpartum depression and overeating: The study in mice suggests the so-called "love hormone" -- oxytocin -- may ease symptoms. Obesity and postpartum depression are major health problems worldwide.
The new study, published July 2 in the journal , is an outgrowth of research by scientists at Baylor College of Medicine in Houston and the University of Cambridge in the U.K. They were studying two boys from different families who were severely obese.
The boys had autism, anxiety and behavior problems triggered by smells or sounds. Both were missing a gene called TRP5. They inherited the gene deletion from their mothers, who also were missing the gene.
Both women were obese and had experienced postpartum depression. To find out if the missing TRPC5 gene was causing problems in the boys and their moms, researchers put genetic engineering to work. They produced mice with a defective version of the gene — called Trpc5 in mice.
"What we saw in those mice was quite remarkable," said study co-author , associate director for basic sciences.
