In a recent review published in the journal Nature Reviews Cardiology , a group of authors reviewed the Low-Density Lipoprotein (LDL) (a type of cholesterol that can build up in artery walls) cumulative exposure hypothesis and its implications for atherosclerotic cardiovascular disease (ASCVD) (a condition caused by the buildup of plaques in the arteries) prevention. Review Article: The LDL cumulative exposure hypothesis: evidence and practical applications . Image Credit: Explode / Shutterstock ASCVD is the leading cause of morbidity and mortality worldwide.
It is caused by the progressive trapping of cholesterol-carrying LDL and other apolipoprotein B(APOB)-containing lipoproteins within the arterial wall. Over time, as more LDL particles become trapped, atherosclerotic plaques grow, increasing the risk of ASCVD events. The effect of LDL on ASCVD depends on both the magnitude and duration of exposure.
Maintaining low LDL-cholesterol (LDL-C) levels over time can reduce atherogenic lipoproteins (Lipoproteins, including LDL, that promote the formation of fatty deposits in the arteries) in the artery wall, slow atherosclerosis ( the process of plaque buildup in the arteries, causing them to harden and narrow) progression, and lower the lifetime risk of ASCVD events. Further research is needed to refine the cumulative exposure hypothesis and develop personalized strategies for effectively lowering LDL-C levels to prevent ASCVD. The review highlights the need for further research.
