Dr. Hui Zhou, Senior Vice President of Innovent Biologics, said, "We are excited to share the latest clinical development updates on IBI343 at ASCO. As an innovative TOPOi ADC, IBI343 showed a positive clinical signal in subjects with advanced pancreatic cancer and the incidence of grade 3 or above gastrointestinal adverse events is low.
It is the first CLDN18.2 ADC to achieve a breakthrough in this difficult-to-treat cancer and shed light on the exploring directions to this therapeutic field. We will continue to follow up on the clinical data update of IBI343.
As one of the few biopharmaceutical companies with leading R&D capabilities in both immunotherapy (IO) and antibody-drug conjugates (ADCs), we will also explore combination therapy of IBI343 and its therapeutic potential in other solid tumors such as gastric cancer for the benefit of more patients." Safety and efficacy of IBI343 (anti-CLDN18.2 ADC) in patients with advanced pancreatic ductal adenocarcinoma or biliary tract cancer: preliminary results from a Phase I study Abstract#:3037 This Phase I study is conducted in China and Australia, aiming to evaluate the safety, tolerability and preliminary efficacy of IBI343 in subjects with advanced solid tumors.
Data on patients with advanced pancreatic ductal adenocarcinoma or biliary tract cancer were presented at this congress. As of December 19, 2023, a total of 35 patients with advanced pancreatic ductal adenocarcinoma (PDAC) or biliary tract cancer (BTC) were enrolled.
