, /PRNewswire/ -- Hyundai Bioscience (CEO Oh Sang-gi), which is preparing for a dengue fever basket clinical trial in , announced on the 24th that it has successfully developed a 'multi-treatment drug for mosquito-borne viral infections, including dengue fever,' using niclosamide as the main ingredient. This treatment, which contains niclosamide as the main active pharmaceutical ingredient, can maintain a blood niclosamide concentration (IC50) to inhibit the proliferation of viruses such as the four serotypes of dengue virus, Zika, Chikungunya, and Yellow Fever, by 50%. To effectively treat dengue fever, the antiviral must be administered early, before the viral load increases significantly.
For early administration, the treatment must be effective not only against dengue fever but also against other mosquito-borne viral diseases with similar symptoms, such as Zika, Chikungunya, and Yellow Fever. Leveraging its patented technology, Hyundai Bioscience has enhanced the bioavailability of niclosamide, enabling it to treat arbovirus infections caused by Zika, Chikungunya, and Yellow Fever viruses in addition to dengue fever. Recently, the company has succeeded in developing a "niclosamide-based multi-treatment for mosquito-borne viral infections" that can maintain an IC50 in the blood to inhibit the replication of these viruses.
Currently, there is no treatment for dengue fever. The dengue virus has four serotypes (DENV-1, DENV-2, DENV-3, DENV-4), each with different IC50 values..
