featured-image

In a recent study published in the journal Gut Pathogens , researchers from China reviewed the metabolism of soy isoflavones (SI) into a metabolite named "equol" by specific gut bacteria and its role in hormone-dependent and non-hormone-dependent cancers. They discussed relevant gut microbiota and molecular mechanisms to understand equol's anti-tumor effects and potential in cancer treatment. Review: Equol: a metabolite of gut microbiota with potential antitumor effects .

Image Credit: NIKCOA / Shutterstock Soybeans and soy products benefit human health due to compounds like SI. Increased SI intake is linked to reduced risks of cardiovascular disease, hormone-dependent cancers, osteoporosis, and menopausal symptoms. SI act as phytoestrogens, binding to estrogen receptors and mimicking estrogen effects.



SI in soybeans are mostly glycosides, which are less bioavailable. Gut microbiota converts these into more bioavailable aglycones. Equol, a key metabolite, binds to estrogen receptors, helping with menopausal symptoms, osteoporosis, and hormone-dependent cancers.

Equol also has anti-androgen and antioxidant properties, contributing to its anti-tumor effects. Despite its promise, further research is needed to fully understand equol's synthesis, metabolism, and mechanisms of action in various tumors. In the present article, researchers explored equol's chemical properties and metabolism, its synthesis by intestinal microbiota, and its role in various tumors, offering insights for.

Back to Health Page