, /PRNewswire/ -- Grey Wolf Therapeutics, a clinical-stage biotechnology company leveraging first-of-its-kind antigen modulation therapies to address the source of immune dysfunction in oncology and autoimmunity, today announced that initial data from the company's ongoing adaptive Phase 1/2 clinical trial of GRWD5769, an investigational first-in-class ERAP1 inhibitor, were reported in a poster presentation at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting. The presented data consisted of preliminary findings from the initial repeat dosing monotherapy module of the study and demonstrated well-tolerated dose dependent target engagement following administration of escalating oral doses of GRWD5769. Importantly, the observed modulation of the human immunopeptidome with GRWD5769 provides clinical proof-of-mechanism for the novel immuno-oncology candidate and its foundational antigen modulation technology.
"We are highly encouraged by the initial data from our ongoing study, highlighted by the achievement of success in the first known attempt to modulate the immunopeptidome for specific therapeutic purposes. These clear signs of target engagement provide compelling support for our antigen modulation strategy in immuno-oncology, which is designed to allow T cells to recognize new targets on tumour cells and drive de novo anti-tumour responses," said , M.D.
, Ph.D., chief medical officer of Grey Wolf Therapeutics.
"The presented data demonstrate a promising tole.
