A recent study published in the journal Nutrients investigates how the incidence of diabetes is associated with altered trimethylamine N-oxide (TMAO) levels. Study: Dynamic changes in gut microbiota-derived metabolite trimethylamine-n-oxide and risk of type 2 diabetes mellitus: potential for dietary changes in diabetes prevention. Image Credit: Proxima Studio / Shutterstock.
com Type 2 diabetes mellitus (T2DM) is a highly prevalent and potentially disabling medical condition that is closely related to lifestyle factors. Diet, for example, is a significant factor that could contribute to T2DM, as well as modulate the gut microbiota. TMAO is a microbial metabolite with significant biological roles in cardiovascular health, inflammatory responses, renal function, platelet activation, and lipid metabolism.
The primary dietary sources of TMAO include marine fish like cod and haddock, as well as shellfish. Choline, phosphatidylcholine, and L-carnitine, typically found in protein-rich foods like meat and eggs, are also precursor molecules for TMAO. TMAO has been identified as a novel independent risk factor associated with atherosclerosis and cardiovascular disease (CVD).
” The biological mechanisms involved in the association between TMAO, atherosclerosis, and CVD may include fatty tissue inflammation and disruption of the insulin signaling pathway, the latter of which can lead to insulin resistance and diabetes. The current study utilized longitudinal data obtained between 2019 an.
