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On the June 25, 2024 episode of introduced her “favorite guest that we could possibly ever have,” her daughter, Sadie Grace Applegate Le Noble. While Sadie said she floated the idea of being a guest as a joke, her mom and podcast co-host, , made it a reality so the 13-year-old could speak about what it’s like to have a parent with multiple sclerosis (MS) and discuss her own health struggles. During the episode, Sadie revealed she's been able to relate to her mom to a certain degree.

Sadie was recently diagnosed with ), an incurable condition that brings about a number of symptoms including dizziness, fatigue and a rapid heart rate, according to the . “I’ve had to live with it for a long time,” Sadie explained. “Last year, in sixth grade, I would go to the nurse multiple times for it because I always felt like I was going to pass out,” Sadie explained.



The nurse, she said, didn’t take her seriously and blamed her symptoms on anxiety. “Them not doing anything about it definitely hurt me physically and emotionally because I was just like, ‘This is rude.’ I feel sick and you are telling me to go to P.

E. and run laps around the football field.” Applegate reveals she didn’t fully understand what was happening with her daughter at first either.

“I felt so horrible that we didn’t pay attention to it,” she said. “I didn’t know that there could be this thing until her best friend got , so that kind of brought it to us.” At home, Applegate said, S.

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