In a systematic review published in the journal Frontiers in Nutrition , researchers in Italy have provided a comprehensive overview of the impact of biological matrices with antioxidant properties in mitigating high-fat diet-induced female reproductive complications. Review: High-fat diet-negative impact on female fertility: from mechanisms to protective actions of antioxidant matrices . Image Credit: DIVA.
photo / Shutterstock High-calorie diets, including diets rich in saturated and trans fats, can negatively impact the female reproductive system by triggering the production of reactive oxygen species (ROS) and subsequently inducing oxidative stress. This can lead to irregular ovulation patterns and premature ovarian failure. Diet-induced ROS production can affect blood flow to the reproductive organs and disrupt the functioning of the hypothalamic-pituitary-ovarian axis.
These processes can collectively cause reproductive hormonal imbalance, induce insulin resistance and hyperleptinemia, promote chronic low-grade inflammation, affect oocyte quality, and impair uterine embryo implantation and pregnancy maintenance. Biological matrices that can positively impact the female reproductive system include carbocyclic sugar, phytonutrients, organosulfur compounds, hormones, neuropeptides, organic acids, and vitamins. These matrices mostly contain a variety of antioxidants that help mitigate ROS-induced oxidative damage in the body.
In this systematic review, the authors have asses.
