The artificial intelligence (AI) model GPT-4, known from its application in ChatGPT, shows impressive capabilities in biomedical research and can be used in many ways for simulations. A simulator developed at MedUni Vienna and based on GPT-4 shows increased accuracy in classifying the importance of genes in cancer cells, as well as in the prognosis of cancer patients. The results of the study were published in the journal Computers in Biology and Medicine.
Large language models such as GPT-4 have proven to be extremely useful in various fields, including biomedicine. A research team from MedUni Vienna's Institute of Artificial Intelligence and the CeMM Research Center for Molecular Medicine, led by Matthias Samwald and Christoph Bock, has shown that a large language model such as GPT-4 can be used effectively as a simulator for biological systems. The study tests the hypothesis that the stepwise simulation of biological and medical processes with GPT-4 leads to better results.
This is relevant for future application in biomedical research as well as for the understanding of these new models. Computer simulations of biological processes are an important tool for biomedical research, but usually require a lot of expertise and manual adjustments. The research team has developed "SimulateGPT", a knowledge-based simulation method through structured inputs in GPT-4.
This method has been tested and validated by experts in various scenarios such as mouse experiments, sepsis treatment.
