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Twenty-one seasons is enough to make your head spin, isn't it? , one of TV's longest-running successes and a record-breaker in its own right, will enter its 21st season this fall. Talk about job security, at least for the show's most senior cast members. But as you can imagine, running a show over the course of nearly two decades means a lot of changes have to be made to keep things fresh.

Between storylines coming to a natural end and cast members leaving on their own, each season of Shonda Rhimes' smash hit has come with cast shakeups. So far, we know that a couple of beloved characters won't be sticking around for the long term: Jake Borelli and Midori Francis have confirmed they will be exiting the show, so we're saying goodbye to Levi Schmidt and Mika Yasuda. We're expecting a return to a longer season this year after season 20 was cut in half due to production delays resulting from Hollywood strikes.



And with several big cliffhangers looming over us since the , the next installment has a lot of ground to cover. In the meantime, we're taking a look at the cast returning for Season 21, starting with those who have been with us since the Grey's Anatomy series premiere. As the show's namesake, Meredith has been the main character and major staple on the show since day one.

The show has evolved quite a lot in recent years, making her into more of a background character, and allowing new generations of doctors to shine. Truth be told, we're not entirely certain how much of Me.

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